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  1. 1Each course of treatment therefore acts as a form of selection, removing susceptible bacteria and leaving the resistant ones to multiply. The more often a drug is used, the faster this process tends to occur.
  2. 2Antibiotics transformed medicine in the twentieth century, turning once-deadly infections into conditions that could usually be cured within days. For several decades, doctors assumed that this advantage would last indefinitely.
  3. 3Scientists are also searching for new classes of drug, but development is slow and costly, so careful use of existing treatments remains the most practical way to protect their effectiveness.
  4. 4For this reason, health authorities now urge doctors to prescribe antibiotics only when they are clearly needed, and to ask patients to follow the instructions they are given.
  5. 5That assumption proved mistaken. Bacteria reproduce so quickly that any individual carrying a chance mutation allowing it to survive a drug will soon be surrounded by many descendants sharing the same trait.

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